Of importance is that responses were noted in 4 patients who had failed testosterone therapy for microphallus. Proper development of the fetal penis requires not just testosterone from the testes, but a second hormone produced by other tissues, including the placenta, according to a new study publishing February 14 in the open-access journal. During development of the male fetus, the testes release testosterone, a steroid hormone which is converted to 5?-dihydrotestosterone (DHT) by the genital tubercle, helping to ensure that this primordial structure develops into a penis, rather than into the female clitoris. All patients demonstrated growth of the penis during treatment. In conclusion, transdermal dihydrotestosterone therapy is an effective and relatively safe modality in the treatment of microphallus.
Transdermal dihydrotestosterone therapy and its effects on patients
As reported in the journal, pLOS Biology, Fowler and collaborators in Glasgow, France and Sweden have conducted a study dihydrotestosterone penis enlargement that explains more about this second process. Our results demonstrate that masculinization of the male fetus depends not only on the testes, but also on other tissues, especially the placenta. However, recent studies have shown that penis development also relies on a second, alternative or backdoor pathway, where DHT is produced independently of testosterone from the testicles. During male fetal development, testosterone from the testes is converted into the male sex hormone 5-dihydrotestosterone (DHT) by the genital tubercle the primordial structure that either develops into a penis or clitoris. Background: The child was born with ambiguous genitalia at full term.
Story Source: Materials provided by, pLOS. They also suggest an explanation for why disorders of placental insufficiency can lead to hypospadias and other abnormalities of growth of the male external genitalia. No female internal genitalia were found. For ages less than and older than 10 years, respectively. The pituitary-gonadal axis was transiently suppressed during treatment, and serum sex hormone binding globulin and lipid metabolism were transiently affected during treatment. Using mass spectrometry, the team measured levels of steroid hormones in fetal plasma and tissue during the second trimester - the most vital phase for penis development.
Topical dihydrotestosterone to treat micropenis secondary to partial
To investigate the efficacy of transdermal dihydrotestosterone therapy on 22 patients with microphallus, we applied dihydrotestosterone gel for 8 weeks to the external genitalia at daily doses.5. Conclusions: We conclude that early treatment with locally applied DHT may have a significant effect on penile growth in 17-beta HSD deficiency. The child was assigned male sex. Since androsterone can be made from progesterone, the authors suggest that placental progesterone or related compounds are the likely source of androsterone in the backdoor pathway. HCG stimulation did not result in an increase in testosterone, but a clinically obvious increase in phallus size. These insights have the potential to make a big difference to how we treat sexual disorders in male babies in future and are also relevant to the whole debate about male and female identity. Given that androsterone can be made from progesterone, Fowler and colleagues suggest that placental progesterone is the androsterone source in the alternative pathway. Subsequent genetic analysis confirmed a 17-beta HSD-deficiency. All patients were evaluated for penile and prostatic growth, pituitary-gonadal axis function, serum sex hormone binding globulin, lipid metabolism, hepatotoxicity, bone age and height velocity. Plos Biology from Paul Fowler of the University of Aberdeen, Michelle Bellingham of the University of Glasgow, and colleagues in the UK, France and Sweden. They also analyzed gene expression levels in various tissues of key enzymes known to be involved in hormone synthesis. The researchers also measured gene expression in tissues known to be involved in hormone synthesis. Investigations revealed 46,XY karyotype, testosterone and DHT levels were.5 nmol/L and.1 nmol/L respectively.
DHT (Dihydrotestosterone) Balancing it towards Penis Growth
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